Please use this identifier to cite or link to this item:
Title: The antithrombotic effect of dextran-40 in man is due to enhanced fibrinolysis in vivo.
Authors: Jones, CI
Payne, DA
Hayes, PD
Naylor, AR
Bell, PR
Thompson, MM
Goodall, AH
First Published: Sep-2008
Citation: J VASC SURG, 2008, 48 (3), pp. 715-722
Abstract: Dextran-40 is effective in reducing postoperative Doppler-detectable embolization in patients undergoing carotid endarterectomy (CEA). Dextrans are thought to have antithrombotic and antiplatelet effects. The mode of action is unclear. In rats, dextran blocks uptake of tissue plasminogen activator (tPA) by mannose-binding receptors. Because this would have the effect of enhancing endogenous fibrinolysis, we explored this effect of dextran-40 on fibrinolysis in man.
DOI Link: 10.1016/j.jvs.2008.04.008
eISSN: 1097-6809
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

Files in This Item:
There are no files associated with this item.

Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.