Please use this identifier to cite or link to this item:
Title: The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.
Authors: Helgadottir, A
Manolescu, A
Thorleifsson, G
Gretarsdottir, S
Jonsdottir, H
Thorsteinsdottir, U
Samani, NJ
Gudmundsson, G
Grant, SF
Thorgeirsson, G
Sveinbjornsdottir, S
Valdimarsson, EM
Matthiasson, SE
Johannsson, H
Gudmundsdottir, O
Gurney, ME
Sainz, J
Thorhallsdottir, M
Andresdottir, M
Frigge, ML
Topol, EJ
Kong, A
Gudnason, V
Hakonarson, H
Gulcher, JR
Stefansson, K
First Published: Mar-2004
Citation: NAT GENET, 2004, 36 (3), pp. 233-239
Abstract: We mapped a gene predisposing to myocardial infarction to a locus on chromosome 13q12-13. A four-marker single-nucleotide polymorphism (SNP) haplotype in this locus spanning the gene ALOX5AP encoding 5-lipoxygenase activating protein (FLAP) is associated with a two times greater risk of myocardial infarction in Iceland. This haplotype also confers almost two times greater risk of stroke. Another ALOX5AP haplotype is associated with myocardial infarction in individuals from the UK. Stimulated neutrophils from individuals with myocardial infarction produce more leukotriene B4, a key product in the 5-lipoxygenase pathway, than do neutrophils from controls, and this difference is largely attributed to cells from males who carry the at-risk haplotype. We conclude that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall.
DOI Link: 10.1038/ng1311
ISSN: 1061-4036
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

Files in This Item:
There are no files associated with this item.

Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.