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Title: The long-term effects of open and endovascular aneurysm repair on circulating interleukin-6.
Authors: Dawson, JA
Choke, E
Cockerill, GW
Loftus, IM
Thompson, MM
First Published: Jan-2009
Citation: EUR J VASC ENDOVASC SURG, 2009, 37 (1), pp. 43-45
Abstract: Interleukin-6 (IL-6) is associated with abdominal aortic aneurysm (AAA) development and is an independent risk factor for cardiovascular mortality. We tested the hypothesis that aneurysm repair reduces circulating IL-6 by comparing concentrations in patients with large AAA awaiting repair (n=50) with patients having undergone open (n=34) or endovascular (n=66) repair. Only open repair was associated with a significant reduction in IL-6 (p=0.025). These results suggest that AAAs remain biologically active following endovascular repair. Aneurysm-derived IL-6 may have serious implications for cardiovascular health, and attention should be directed to modifying cardiovascular risk factors in these patients, even after successful aneurysm repair.
DOI Link: 10.1016/j.ejvs.2008.09.025
eISSN: 1532-2165
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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