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Title: The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential.
Authors: Lambert, DG
First Published: Aug-2008
Citation: NAT REV DRUG DISCOV, 2008, 7 (8), pp. 694-710
Abstract: Identification of the enigmatic nociceptin/orphanin FQ peptide (N/OFQ) in 1995 represented the first successful use of reverse pharmacology and led to deorphanization of the N/OFQ receptor (NOP). Subsequently, the N/OFQ-NOP system has been implicated in a wide range of biological functions, including pain, drug abuse, cardiovascular control and immunity. Although this could be considered a hurdle for the development of pharmaceuticals selective for a specific disease indication, NOP represents a viable drug target. This article describes potential clinical indications and highlights the current status of the very limited number of clinical trials.
DOI Link: 10.1038/nrd2572
eISSN: 1474-1784
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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