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Title: TNF-alpha gene promoter polymorphism at nucleotide -308 and the inflammatory response and oxidative stress induced by cardiac surgery: role of heart failure and medical treatment.
Authors: Galiñanes, M
James, M
Codd, V
Baxi, A
Hadjinikolaou, L
First Published: Aug-2008
Citation: EUR J CARDIOTHORAC SURG, 2008, 34 (2), pp. 332-337
Abstract: Increased TNF-alpha during cardiac surgery is thought to be responsible for perioperative complications. The TNF-alpha gene promoter polymorphism G/A at position -308 has been associated with enhanced TNF-alpha secretion, as has been heart failure. Therefore, the aims of this study were to investigate: (i) whether the TNF-alpha G/A polymorphism is associated with exacerbation of TNF-alpha plasma levels during cardiac surgery; (ii) whether TNF-alpha production is further increased by heart failure and influenced by medical treatment; and (iii) whether this polymorphism is associated with increased oxidative stress and perioperative complications.
DOI Link: 10.1016/j.ejcts.2008.03.015
ISSN: 1010-7940
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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