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Title: Unstable carotid plaques exhibit raised matrix metalloproteinase-8 activity.
Authors: Molloy, KJ
Thompson, MM
Jones, JL
Schwalbe, EC
Bell, PR
Naylor, AR
Loftus, IM
First Published: 20-Jul-2004
Citation: CIRCULATION, 2004, 110 (3), pp. 337-343
Abstract: The fibrous cap of atherosclerotic plaques is composed predominantly of type I and III collagen. Unstable carotid plaques are characterized by rupture of their cap, leading to thromboembolism and stroke. The proteolytic mechanisms causing plaque disruption are undefined, but the collagenolytic matrix metalloproteinase (MMP) -1, -8, and -13 may be implicated. The aim of this study was to quantify the concentrations of these collagenases in carotid plaques and to determine their relationship to markers of plaque instability.
DOI Link: 10.1161/01.CIR.0000135588.65188.14
eISSN: 1524-4539
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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