Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/17677
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dc.contributor.authorMolloy, KJ-
dc.contributor.authorThompson, MM-
dc.contributor.authorJones, JL-
dc.contributor.authorSchwalbe, EC-
dc.contributor.authorBell, PR-
dc.contributor.authorNaylor, AR-
dc.contributor.authorLoftus, IM-
dc.date.accessioned2012-10-24T09:04:15Z-
dc.date.available2012-10-24T09:04:15Z-
dc.date.issued2004-7-20-
dc.identifier.citationCIRCULATION, 2004, 110 (3), pp. 337-343-
dc.identifier.urihttp://hdl.handle.net/2381/17677-
dc.description.abstractThe fibrous cap of atherosclerotic plaques is composed predominantly of type I and III collagen. Unstable carotid plaques are characterized by rupture of their cap, leading to thromboembolism and stroke. The proteolytic mechanisms causing plaque disruption are undefined, but the collagenolytic matrix metalloproteinase (MMP) -1, -8, and -13 may be implicated. The aim of this study was to quantify the concentrations of these collagenases in carotid plaques and to determine their relationship to markers of plaque instability.-
dc.formatmetadata-
dc.language.isoeng-
dc.sourcePubMed-
dc.source.urihttp://www.ncbi.nlm.nih.gov/pubmed/-
dc.subjectAged-
dc.subjectCarotid Artery Diseases-
dc.subjectFemale-
dc.subjectHumans-
dc.subjectImmunohistochemistry-
dc.subjectIn Situ Hybridization-
dc.subjectIntracranial Embolism-
dc.subjectMale-
dc.subjectMatrix Metalloproteinase 8-
dc.subjectMatrix Metalloproteinases-
dc.subjectMiddle Aged-
dc.subjectRNA-
dc.subjectMessenger-
dc.subjectTissue Inhibitor of Metalloproteinases-
dc.titleUnstable carotid plaques exhibit raised matrix metalloproteinase-8 activity.-
dc.typeJournal Article-
dc.identifier.doi10.1161/01.CIR.0000135588.65188.14-
dc.identifier.eissn1524-4539-
dc.identifier.pii01.CIR.0000135588.65188.14-
dc.description.irispid21641-
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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