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Title: Vertical optokinetic nystagmus in Parkinson's disease.
Authors: Knapp, CM
Gottlob, I
McLean, RJ
Rajabally, YA
Abbott, RJ
Rafelt, S
Proudlock, FA
First Published: 30-Jul-2009
Citation: MOV DISORD, 2009, 24 (10), pp. 1533-1538
Abstract: Parkinson's disease (PD) is associated with a number of oculomotor deficits; however, little is known about changes in vertical optokinetic nystagmus (OKN) associated with PD. We recorded eye movements in 14 PD patients and 14 age-matched controls in response to large field OKN stimulation using stimulus velocities of 20 degrees /second and 40 degrees /second. We compared asymmetry of horizontal and vertical responses in the two groups. We found vertical OKN to be strongly asymmetric in PD with reduced gains for downward-moving stimuli. This asymmetry was significantly greater than that recorded in control volunteers. We postulate that this could result from an abnormal pursuit/early OKN system in PD leading to greater influence of the delayed OKN system.
DOI Link: 10.1002/mds.22634
eISSN: 1531-8257
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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