Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/17772
Title: Circadian rhythm entrainment in flies and mammals.
Authors: Ben-Shlomo, R
Kyriacou, CP
First Published: 2002
Citation: CELL BIOCHEM BIOPHYS, 2002, 37 (2), pp. 141-156
Abstract: Circadian rhythms are a fundamental adaptation of living cells to the daily and seasonal fluctuation in light and temperature. Circadian oscillations persist in constant conditions; however, they are also phase-adjusted (entrained) by day-night cycles. It is this entrainability that provides for the proper phasing of the program, to the sequence of external changes that it has evolved to exploit. Synchronization of circadian oscillators with the outside world is achieved because light, temperature, or other external temporal cues, have acute effects on the levels of one or more of the clock's components. The consequences are ripples through the interconnected molecular loops, leading to a stable phase realignment of the endogenous rhythm generator and the external conditions. This review summarized the evolving knowledge of the different types, modes, and molecular processes of entrainment in flies and mammals.
DOI Link: 10.1385/CBB:37:2:141
ISSN: 1085-9195
Links: http://hdl.handle.net/2381/17772
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Genetics

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