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Title: Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
Authors: Schunkert, H
König, IR
Kathiresan, S
Reilly, MP
Assimes, TL
Holm, H
Preuss, M
Stewart, AF
Barbalic, M
Gieger, C
Absher, D
Aherrahrou, Z
Allayee, H
Altshuler, D
Anand, SS
Andersen, K
Anderson, JL
Ardissino, D
Ball, SG
Balmforth, AJ
Barnes, TA
Becker, DM
Becker, LC
Berger, K
Bis, JC
Boekholdt, SM
Boerwinkle, E
Braund, PS
Brown, MJ
Burnett, MS
Buysschaert, I
Carlquist, JF
Chen, L
Cichon, S
Codd, V
Davies, RW
Dedoussis, G
Dehghan, A
Demissie, S
Devaney, JM
Diemert, P
Do, R
Doering, A
Eifert, S
Mokhtari, NE
Ellis, SG
Elosua, R
Engert, JC
Epstein, SE
de Faire U
Fischer, M
Folsom, AR
Freyer, J
Gigante, B
Girelli, D
Gretarsdottir, S
Gudnason, V
Gulcher, JR
Halperin, E
Hammond, N
Hazen, SL
Hofman, A
Horne, BD
Illig, T
Iribarren, C
Jones, GT
Jukema, JW
Kaiser, MA
Kaplan, LM
Kastelein, JJ
Khaw, KT
Knowles, JW
Kolovou, G
Kong, A
Laaksonen, R
Lambrechts, D
Leander, K
Lettre, G
Li, M
Lieb, W
Loley, C
Lotery, AJ
Mannucci, PM
Maouche, S
Martinelli, N
McKeown, PP
Meisinger, C
Meitinger, T
Melander, O
Merlini, PA
Mooser, V
Morgan, T
Mühleisen, TW
Muhlestein, JB
Münzel, T
Musunuru, K
Nahrstaedt, J
Nelson, CP
Nöthen, MM
Olivieri, O
Patel, RS
Patterson, CC
Peters, A
Peyvandi, F
Qu, L
Quyyumi, AA
Rader, DJ
Rallidis, LS
Rice, C
Rosendaal, FR
Rubin, D
Salomaa, V
Sampietro, ML
Sandhu, MS
Schadt, E
Schäfer, A
Schillert, A
Schreiber, S
Schrezenmeir, J
Schwartz, SM
Siscovick, DS
Sivananthan, M
Sivapalaratnam, S
Smith, A
Smith, TB
Snoep, JD
Soranzo, N
Spertus, JA
Stark, K
Stirrups, K
Stoll, M
Tang, WH
Tennstedt, S
Thorgeirsson, G
Thorleifsson, G
Tomaszewski, M
Uitterlinden, AG
van Rij AM
Voight, BF
Wareham, NJ
Wells, GA
Wichmann, HE
Wild, PS
Willenborg, C
Witteman, JC
Wright, BJ
Ye, S
Zeller, T
Ziegler, A
Cambien, F
Goodall, AH
Cupples, LA
Quertermous, T
März, W
Hengstenberg, C
Blankenberg, S
Ouwehand, WH
Hall, AS
Deloukas, P
Thompson, JR
Stefansson, K
Roberts, R
Thorsteinsdottir, U
O'Donnell, CJ
McPherson, R
Erdmann, J
CARDIoGRAM, Consortium
Samani, NJ
First Published: Apr-2011
Citation: NAT GENET, 2011, 43 (4), pp. 333-338
Abstract: We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 × 10⁻⁸ and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.
DOI Link: 10.1038/ng.784
eISSN: 1546-1718
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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