Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/17839
Title: Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
Authors: Wain, LV
Verwoert, GC
O'Reilly, PF
Shi, G
Johnson, T
Johnson, AD
Bochud, M
Rice, KM
Henneman, P
Smith, AV
Ehret, GB
Amin, N
Larson, MG
Mooser, V
Hadley, D
Dörr, M
Bis, JC
Aspelund, T
Esko, T
Janssens, AC
Zhao, JH
Heath, S
Laan, M
Fu, J
Pistis, G
Luan, J
Arora, P
Lucas, G
Pirastu, N
Pichler, I
Jackson, AU
Webster, RJ
Zhang, F
Peden, JF
Schmidt, H
Tanaka, T
Campbell, H
Igl, W
Milaneschi, Y
Hottenga, JJ
Vitart, V
Chasman, DI
Trompet, S
Bragg-Gresham, JL
Alizadeh, BZ
Chambers, JC
Guo, X
Lehtimäki, T
Kühnel, B
Lopez, LM
Polašek, O
Boban, M
Nelson, CP
Morrison, AC
Pihur, V
Ganesh, SK
Hofman, A
Kundu, S
Mattace-Raso, FU
Rivadeneira, F
Sijbrands, EJ
Uitterlinden, AG
Hwang, SJ
Vasan, RS
Wang, TJ
Bergmann, S
Vollenweider, P
Waeber, G
Laitinen, J
Pouta, A
Zitting, P
McArdle, WL
Kroemer, HK
Völker, U
Völzke, H
Glazer, NL
Taylor, KD
Harris, TB
Alavere, H
Haller, T
Keis, A
Tammesoo, ML
Aulchenko, Y
Barroso, I
Khaw, KT
Galan, P
Hercberg, S
Lathrop, M
Eyheramendy, S
Org, E
Sõber, S
Lu, X
Nolte, IM
Penninx, BW
Corre, T
Masciullo, C
Sala, C
Groop, L
Voight, BF
Melander, O
O'Donnell, CJ
Salomaa, V
d'Adamo, AP
Fabretto, A
Faletra, F
Ulivi, S
Del Greco F
Facheris, M
Collins, FS
Bergman, RN
Beilby, JP
Hung, J
Musk, AW
Mangino, M
Shin, SY
Soranzo, N
Watkins, H
Goel, A
Hamsten, A
Gider, P
Loitfelder, M
Zeginigg, M
Hernandez, D
Najjar, SS
Navarro, P
Wild, SH
Corsi, AM
Singleton, A
de Geus EJ
Willemsen, G
Parker, AN
Rose, LM
Buckley, B
Stott, D
Orru, M
Uda, M
LifeLines Cohort Study
van der Klauw MM
Zhang, W
Li, X
Scott, J
Chen, YD
Burke, GL
Kähönen, M
Viikari, J
Döring, A
Meitinger, T
Davies, G
Starr, JM
Emilsson, V
Plump, A
Lindeman, JH
Hoen, PA
König, IR
EchoGen, consortium
Felix, JF
Clarke, R
Hopewell, JC
Ongen, H
Breteler, M
Debette, S
Destefano, AL
Fornage, M
AortaGen, Consortium
Mitchell, GF
CHARGE Consortium Heart Failure Working Group
Smith, NL
KidneyGen, consortium
Holm, H
Stefansson, K
Thorleifsson, G
Thorsteinsdottir, U
CKDGen, consortium
Cardiogenics, consortium
CardioGram
Samani, NJ
Preuss, M
Rudan, I
Hayward, C
Deary, IJ
Wichmann, HE
Raitakari, OT
Palmas, W
Kooner, JS
Stolk, RP
Jukema, JW
Wright, AF
Boomsma, DI
Bandinelli, S
Gyllensten, UB
Wilson, JF
Ferrucci, L
Schmidt, R
Farrall, M
Spector, TD
Palmer, LJ
Tuomilehto, J
Pfeufer, A
Gasparini, P
Siscovick, D
Altshuler, D
Loos, RJ
Toniolo, D
Snieder, H
Gieger, C
Meneton, P
Wareham, NJ
Oostra, BA
Metspalu, A
Launer, L
Rettig, R
Strachan, DP
Beckmann, JS
Witteman, JC
Erdmann, J
van Dijk KW
Boerwinkle, E
Boehnke, M
Ridker, PM
Jarvelin, MR
Chakravarti, A
Abecasis, GR
Gudnason, V
Newton-Cheh, C
Levy, D
Munroe, PB
Psaty, BM
Caulfield, MJ
Rao, DC
Tobin, MD
Elliott, P
van Duijn CM
First Published: Oct-2011
Citation: NAT GENET, 2011, 43 (10), pp. 1005-1011
Abstract: Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.
DOI Link: 10.1038/ng.922
eISSN: 1546-1718
Links: http://hdl.handle.net/2381/17839
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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