Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/17840
Title: Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
Authors: International Consortium for Blood Pressure Genome-Wide Association Studies
Ehret, GB
Munroe, PB
Rice, KM
Bochud, M
Johnson, AD
Chasman, DI
Smith, AV
Tobin, MD
Verwoert, GC
Hwang, SJ
Pihur, V
Vollenweider, P
O'Reilly, PF
Amin, N
Bragg-Gresham, JL
Teumer, A
Glazer, NL
Launer, L
Zhao, JH
Aulchenko, Y
Heath, S
Sõber, S
Parsa, A
Luan, J
Arora, P
Dehghan, A
Zhang, F
Lucas, G
Hicks, AA
Jackson, AU
Peden, JF
Tanaka, T
Wild, SH
Rudan, I
Igl, W
Milaneschi, Y
Parker, AN
Fava, C
Chambers, JC
Fox, ER
Kumari, M
Go, MJ
van der Harst P
Kao, WH
Sjögren, M
Vinay, DG
Alexander, M
Tabara, Y
Shaw-Hawkins, S
Whincup, PH
Liu, Y
Shi, G
Kuusisto, J
Tayo, B
Seielstad, M
Sim, X
Nguyen, KD
Lehtimäki, T
Matullo, G
Wu, Y
Gaunt, TR
Onland-Moret, NC
Cooper, MN
Platou, CG
Org, E
Hardy, R
Dahgam, S
Palmen, J
Vitart, V
Braund, PS
Kuznetsova, T
Uiterwaal, CS
Adeyemo, A
Palmas, W
Campbell, H
Ludwig, B
Tomaszewski, M
Tzoulaki, I
Palmer, ND
CARDIoGRAM, consortium
CKDGen, Consortium
KidneyGen, Consortium
EchoGen, consortium
CHARGE-HF, consortium
Aspelund, T
Garcia, M
Chang, YP
O'Connell, JR
Steinle, NI
Grobbee, DE
Arking, DE
Kardia, SL
Morrison, AC
Hernandez, D
Najjar, S
McArdle, WL
Hadley, D
Brown, MJ
Connell, JM
Hingorani, AD
Day, IN
Lawlor, DA
Beilby, JP
Lawrence, RW
Clarke, R
Hopewell, JC
Ongen, H
Dreisbach, AW
Li, Y
Young, JH
Bis, JC
Kähönen, M
Viikari, J
Adair, LS
Lee, NR
Chen, MH
Olden, M
Pattaro, C
Bolton, JA
Köttgen, A
Bergmann, S
Mooser, V
Chaturvedi, N
Frayling, TM
Islam, M
Jafar, TH
Erdmann, J
Kulkarni, SR
Bornstein, SR
Grässler, J
Groop, L
Voight, BF
Kettunen, J
Howard, P
Taylor, A
Guarrera, S
Ricceri, F
Emilsson, V
Plump, A
Barroso, I
Khaw, KT
Weder, AB
Hunt, SC
Sun, YV
Bergman, RN
Collins, FS
Bonnycastle, LL
Scott, LJ
Stringham, HM
Peltonen, L
Perola, M
Vartiainen, E
Brand, SM
Staessen, JA
Wang, TJ
Burton, PR
Soler Artigas M
Dong, Y
Snieder, H
Wang, X
Zhu, H
Lohman, KK
Rudock, ME
Heckbert, SR
Smith, NL
Wiggins, KL
Doumatey, A
Shriner, D
Veldre, G
Viigimaa, M
Kinra, S
Prabhakaran, D
Tripathy, V
Langefeld, CD
Rosengren, A
Thelle, DS
Corsi, AM
Singleton, A
Forrester, T
Hilton, G
McKenzie, CA
Salako, T
Iwai, N
Kita, Y
Ogihara, T
Ohkubo, T
Okamura, T
Ueshima, H
Umemura, S
Eyheramendy, S
Meitinger, T
Wichmann, HE
Cho, YS
Kim, HL
Lee, JY
Scott, J
Sehmi, JS
Zhang, W
Hedblad, B
Nilsson, P
Smith, GD
Wong, A
Narisu, N
Stančáková, A
Raffel, LJ
Yao, J
Kathiresan, S
O'Donnell, CJ
Schwartz, SM
Ikram, MA
Longstreth, WT
Mosley, TH
Seshadri, S
Shrine, NR
Wain, LV
Morken, MA
Swift, AJ
Laitinen, J
Prokopenko, I
Zitting, P
Cooper, JA
Humphries, SE
Danesh, J
Rasheed, A
Goel, A
Hamsten, A
Watkins, H
Bakker, SJ
van Gilst WH
Janipalli, CS
Mani, KR
Yajnik, CS
Hofman, A
Mattace-Raso, FU
Oostra, BA
Demirkan, A
Isaacs, A
Rivadeneira, F
Lakatta, EG
Orru, M
Scuteri, A
Ala-Korpela, M
Kangas, AJ
Lyytikäinen, LP
Soininen, P
Tukiainen, T
Würtz, P
Ong, RT
Dörr, M
Kroemer, HK
Völker, U
Völzke, H
Galan, P
Hercberg, S
Lathrop, M
Zelenika, D
Deloukas, P
Mangino, M
Spector, TD
Zhai, G
Meschia, JF
Nalls, MA
Sharma, P
Terzic, J
Kumar, MV
Denniff, M
Zukowska-Szczechowska, E
Wagenknecht, LE
Fowkes, FG
Charchar, FJ
Schwarz, PE
Hayward, C
Guo, X
Rotimi, C
Bots, ML
Brand, E
Samani, NJ
Polasek, O
Talmud, PJ
Nyberg, F
Kuh, D
Laan, M
Hveem, K
Palmer, LJ
van der Schouw YT
Casas, JP
Mohlke, KL
Vineis, P
Raitakari, O
Ganesh, SK
Wong, TY
Tai, ES
Cooper, RS
Laakso, M
Rao, DC
Harris, TB
Morris, RW
Dominiczak, AF
Kivimaki, M
Marmot, MG
Miki, T
Saleheen, D
Chandak, GR
Coresh, J
Navis, G
Salomaa, V
Han, BG
Zhu, X
Kooner, JS
Melander, O
Ridker, PM
Bandinelli, S
Gyllensten, UB
Wright, AF
Wilson, JF
Ferrucci, L
Farrall, M
Tuomilehto, J
Pramstaller, PP
Elosua, R
Soranzo, N
Sijbrands, EJ
Altshuler, D
Loos, RJ
Shuldiner, AR
Gieger, C
Meneton, P
Uitterlinden, AG
Wareham, NJ
Gudnason, V
Rotter, JI
Rettig, R
Uda, M
Strachan, DP
Witteman, JC
Hartikainen, AL
Beckmann, JS
Boerwinkle, E
Vasan, RS
Boehnke, M
Larson, MG
Järvelin, MR
Psaty, BM
Abecasis, GR
Chakravarti, A
Elliott, P
van Duijn CM
Newton-Cheh, C
Levy, D
Caulfield, MJ
Johnson, T
First Published: 6-Oct-2011
Citation: NATURE, 2011, 478 (7367), pp. 103-109
Abstract: Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or  ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.
DOI Link: 10.1038/nature10405
eISSN: 1476-4687
Links: http://hdl.handle.net/2381/17840
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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