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Title: Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population.
Authors: Tobin, MD
Raleigh, SM
Newhouse, S
Braund, P
Bodycote, C
Ogleby, J
Cross, D
Gracey, J
Hayes, S
Smith, T
Ridge, C
Caulfield, M
Sheehan, NA
Munroe, PB
Burton, PR
Samani, NJ
First Published: 29-Nov-2005
Citation: CIRCULATION, 2005, 112 (22), pp. 3423-3429
Abstract: Blood pressure (BP) is a heritable trait of major public health concern. The WNK1 and WNK4 genes, which encode proteins in the WNK family of serine-threonine kinases, are involved in renal electrolyte homeostasis. Mutations in the WNK1 and WNK4 genes cause a rare monogenic hypertensive syndrome, pseudohypoaldosteronism type II. We investigated whether polymorphisms in these WNK genes influence BP in the general population.
DOI Link: 10.1161/CIRCULATIONAHA.105.555474
eISSN: 1524-4539
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Health Sciences

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