Please use this identifier to cite or link to this item:
|Title:||Analysis of degradation data of poly(l-lactide-co-l,d-lactide) and poly(l-lactide) obtained at elevated and physiological temperatures using mathematical models.|
|Citation:||ACTA BIOMATER, 2010, 6 (10), pp. 3882-3889|
|Abstract:||The degradation of resorbable polymeric devices often takes months to years. Accelerated testing at elevated temperatures is an attractive but controversial technique. The purposes of this paper include: (a) to provide a summary of the mathematical models required to analyse accelerated degradation data and to indicate the pitfalls of using these models; (b) to improve the model previously developed by Han and Pan; (c) to provide a simple version of the model of Han and Pan with an analytical solution that is convenient to use; (d) to demonstrate the application of the improved model in two different poly(lactic acid) systems. It is shown that the simple analytical relations between molecular weight and degradation time widely used in the literature can lead to inadequate conclusions. In more general situations the rate equations are only part of a complete degradation model. Together with previous works in the literature, our study calls for care in using the accelerated testing technique.|
|Appears in Collections:||Published Articles, Dept. of Engineering|
Files in This Item:
There are no files associated with this item.
Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.