Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/2083
Title: Comparative analysis of the α-like globin clusters in mouse, rat and human chromosomes indicates a mechanism underlying breaks in conserved synteny.
Authors: Tufarelli, Cristina
Hardison, Ross
Miller, Webb
Hughes, Jim
Clark, Kevin
Ventress, Nicki
Frischauf, Anna-Marie
Higgs, Douglas R.
First Published: Apr-2004
Publisher: Cold Spring Harbor Laboratory
Citation: Genome Research, 2004, 14 (4), pp. 623-630
Abstract: We have sequenced and fully annotated a 65,871-bp region of mouse Chromosome 17 including the Hba-ps4 α-globin pseudogene. Comparative sequence analysis with the functional α-globin loci at human Chromosome 16p13.3 and mouse Chromosome 11 shows that this segment of mouse Chromosome 17 contains a group of three α-like pseudogenes (Hba-psm–Hba-ps4–Hba-q3), similar to the duplicated sets found at the functional mouse cluster on Chromosome 11. In addition, exons 7 to 12 of the mLuc7L gene are present just downstream from the pseudogene cluster, indicating that this clone contains the region in which human 16p13.3 switches in synteny between mouse Chromosomes 11 and 17. Comparison of the sequences around the α-like clusters on the two mouse chromosomes reveals the presence of conserved tandem repeats. We propose that these repetitive elements have played a role in the fragmentation of the mouse α cluster during evolution.
DOI Link: 10.1101/gr.2143604
ISSN: 1088-9051
eISSN: 1549-5469
Links: http://hdl.handle.net/2381/2083
http://genome.cshlp.org/content/14/4/623
Version: Publisher Version
Status: Peer-reviewed
Type: Article
Rights: Copyright © 2004 by Cold Spring Harbor Laboratory. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.
Appears in Collections:Published Articles, Dept. of Genetics

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