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Title: Body mass and fat mass in refractory asthma: an observational 1 year follow-up study
Authors: Bafadhel, Mona
Singapuri, Amisha
Terry, Sarah
Hargadon, Beverley
Monteiro, William
Green, Ruth H.
Bradding, Peter H.
Wardlaw, Andrew J.
Pavord, Ian D.
Brightling, Christopher E.
First Published: 2010
Publisher: Hindawi Publishing Corporation
Citation: Journal of Allergy (CAIRO), 2010, 2010, pp. 251758
Abstract: Background. Asthma and obesity are common; however the impact of obesity upon asthma remains uncertain. Objectives. To assess relationships between obesity and fat mass with airway inflammation, lung function, and disease control in patients with refractory asthma. Methods. 151 refractory asthma patients were characterised for measures of airway inflammation, lung function, Juniper asthma control questionnaire (JACQ), body mass index (BMI), and fat mass index (FMI) derived from dual energy X-ray absorptiometry. Patients were reassessed over 12 months. Results. 74% of patients had an elevated BMI. BMI and FMI correlated (r = 0.9, P < .001). FMI and JACQ correlated in men (r = 0.3, P = .01). After 12 months 23% lost weight. Weight change over 12 months correlated with FEV(1) change (r = -0.3, P = .03), but not with change in JACQ or exacerbations. Conclusion. Increased fat mass is common in refractory asthma and is associated with asthma symptom control in men. Loss of weight is associated with improvement in lung function in refractory asthma.
DOI Link: 10.1155/2010/251758
eISSN: 1687-9791
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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