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Title: Abnormal segregation of alleles in CEPH pedigree DNAs arising from allele loss in lymphoblastoid DNA.
Authors: Royle, NJ
Armour, JA
Crosier, M
Jeffreys, AJ
First Published: Jan-1993
Citation: GENOMICS, 1993, 15 (1), pp. 119-122
Abstract: Somatic events that result in the reduction to hemi- or homozygosity at all loci affected by the event have been identified in lymphoblastoid DNA from mothers of two CEPH families. Using suitably informative probes, the allele deficiencies were detected by the abnormal transmission of alleles from grandparents to grandchildren, with the apparent absence of the alleles from the parent. Undetected somatic deficiencies in family DNAs could result in misscoring of recombination events and consequently introduce errors into linkage analysis.
DOI Link: 10.1006/geno.1993.1019
ISSN: 0888-7543
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Genetics

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