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|Title:||DETECTION OF A NOVEL MINISATELLITE-SPECIFIC DNA-BINDING PROTEIN|
Jeffreys, Alec J.
|Publisher:||Oxford University Press (OUP)|
|Citation:||Nucleic Acids Research, 1990, 18 (3), pp. 625-629|
|Abstract:||We describe the detection of a ubiquitous DNA-binding protein which appears to interact specifically with tandem-repeated minisatellites. The murine 40kd protein, which we term Msbp-1, was found to be present in all mouse tissues tested. This protein was bound specifically and with high affinity by double-stranded DNA containing a repeat sequence related to the minisatellite ‘core’ sequence, and binding required the presence of multiple repeat units. Corresponding minisatellite-specific DNA-binding proteins could also be detected in species ranging from Drosophila to man. This analysis represents the first direct evidence that minisatellites can function as a specific recognition signal for an endogenous DNA-binding protein.|
|Appears in Collections:||Published Articles, Dept. of Genetics|
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