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Title: A tetranucleotide repeat mouse minisatellite displaying substantial somatic instability during early preimplantation development.
Authors: Gibbs, M
Collick, A
Kelly, RG
Jeffreys, AJ
First Published: Jul-1993
Citation: GENOMICS, 1993, 17 (1), pp. 121-128
Abstract: The highly variable mouse minisatellite Hm-2 is located on chromosome 9 and consists of GGCA tetranucleotide repeats with alleles containing up to 5000 repeat units. This locus is unstable with a germline mutation rate to new length alleles of at least 3.6% per gamete. Hm-2 also shows substantial somatic instability, producing mutational mosaicism detectable in 20% of adult mice. Analysis of allele dosage in mice carrying somatic mutations, plus studies of mosaicism in mouse embryos and extraembryonic tissues, suggests that somatic mutant alleles preferentially arise during preimplantation development and particularly during the first two cell divisions after fertilization.
DOI Link: 10.1006/geno.1993.1292
ISSN: 0888-7543
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Genetics

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