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Title: Proteinuria induces tubular cell turnover: A potential mechanism for tubular atrophy.
Authors: Thomas, ME
Brunskill, NJ
Harris, KP
Bailey, E
Pringle, JH
Furness, PN
Walls, J
First Published: Mar-1999
Citation: KIDNEY INT, 1999, 55 (3), pp. 890-898
Abstract: Proteinuria and tubular atrophy have both been closely linked with progressive renal failure. We hypothesized that apoptosis may be induced by tubular cell exposure to heavy proteinuria, potentially leading to tubular atrophy. Apoptosis was studied in a rat model of "pure" proteinuria, which does not induce renal impairment, namely protein-overload proteinuria.
DOI Link: 10.1046/j.1523-1755.1999.055003890.x
ISSN: 0085-2538
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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