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Title: Different period gene repeats take 'turns' at fine-tuning the circadian clock.
Authors: Guantieri, V
Pepe, A
Zordan, M
Kyriacou, CP
Costa, R
Tamburro, AM
First Published: 22-Nov-1999
Citation: PROC BIOL SCI, 1999, 266 (1435), pp. 2283-2288
Abstract: The repetitive region of the circadian clock gene period in Drosophila pseudoobscura consists predominantly of a pentapeptide sequence whose consensus is NSGAD. In D. melanogaster, this region is replaced by a dipeptide Thr-Gly repeat, which plays a role in the thermal stability of the circadian phenotype. The Thr-Gly repeat has been shown to form a type II or III beta-turn, whose conformational monomer is (Thr-Gly)3. Here we report, using conformational analyses, that both an NSGAD pentapeptide, and a polymer of the same sequence, form type II beta-turns. Thus two peptide sequences, whose amino-acid composition is very different, nevertheless form the same secondary structure. The implications of these structures for clock function are discussed.
DOI Link: 10.1098/rspb.1999.0920
ISSN: 0962-8452
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Genetics

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