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|Title:||Mechanical strain-induced human vascular matrix synthesis: the role of angiotensin II|
|Authors:||Stanley, A. G.|
Knight, A. L.
|Citation:||Journal of the Renin-Angiotensin-Aldosterone System, 2000, 1 (1), pp. 32-35|
|Abstract:||Reduced vascular compliance in patients with hypertension results from an increase in extra-cellular matrix (ECM) protein deposition in blood vessels. At least two key factors, namely mechanical strain and neurohumoral mediators, for example Angiotensin II (Ang II), promote fibrogenesis within vessel walls; however potential interactions between these have not been clearly defined. This work examined the direct effect of mechanical strain on matrix mRNA expression and protein synthesis by human vascular smooth muscle (VSM) cells and identified the importance of renin-angiotensin system (RAS) activation in stretch-induced matrix production.|
|Rights:||Copyright © 2000, SAGE Publications|
|Appears in Collections:||Published Articles, Dept. of Cardiovascular Sciences|
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