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Title: Mechanical strain-induced human vascular matrix synthesis: the role of angiotensin II
Authors: Stanley, A. G.
Patel, H.
Knight, A. L.
Williams, B.
First Published: Mar-2000
Citation: Journal of the Renin-Angiotensin-Aldosterone System, 2000, 1 (1), pp. 32-35
Abstract: Reduced vascular compliance in patients with hypertension results from an increase in extra-cellular matrix (ECM) protein deposition in blood vessels. At least two key factors, namely mechanical strain and neurohumoral mediators, for example Angiotensin II (Ang II), promote fibrogenesis within vessel walls; however potential interactions between these have not been clearly defined. This work examined the direct effect of mechanical strain on matrix mRNA expression and protein synthesis by human vascular smooth muscle (VSM) cells and identified the importance of renin-angiotensin system (RAS) activation in stretch-induced matrix production.
DOI Link: 10.3317/jraas.2000.007
ISSN: 1470-3203
Type: Journal Article
Rights: Copyright © 2000, SAGE Publications
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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