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Title: The erbB-3 gene in human pancreatic cancer.
Authors: Lemoine, NR
Lobresco, M
Leung, H
Barton, C
Hughes, CM
Prigent, SA
Gullick, WJ
Klöppel, G
First Published: Nov-1992
Citation: J PATHOL, 1992, 168 (3), pp. 269-273
Abstract: Abnormalities of the type 1 growth factor receptor family have been implicated in the pathogenesis of pancreatic cancer. There is evidence for a potential autocrine loop involving overexpression of the epidermal growth factor (EGF) receptor and its ligands, as well as overexpression of the erbB-2 receptor. A third member of this receptor family, erbB-3, has recently been recognized and found to be abnormally expressed in some types of human cancer. In this study we show that overexpression of the erbB-3 protein occurs very frequently in carcinoma of the exocrine pancreas and also in chronic pancreatitis. We found no evidence of amplification or rearrangement of the erbB-3 gene by Southern blot analysis of DNA from pancreatic cancer cells lines.
DOI Link: 10.1002/path.1711680305
ISSN: 0022-3417
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Biochemistry

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