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Title: Interleukin 4 is localized to and released by human mast cells
Authors: Bradding, P.
Feather, I. H.
Howarth, P. H.
Mueller, R.
Roberts, J. A.
Britten, K.
Bews, J. P. A.
Hunt, T. C.
Okayama, Y.
Heusser, C. H.
Bullock, G. R.
Church, M. K.
Holgate, S. T.
First Published: 1-Nov-1992
Publisher: Rockefeller University Press
Citation: Journal of Experimental Medicine, 1992, 176 (5), pp. 1381-1386
Abstract: Recent attention has focused on the T helper type 2 (Th2) lymphocyte as a source of interleukin 4 (IL-4) in allergic disease. However, Th2 cells themselves require a pulse of IL-4 to initiate this synthesis. Here we provide immunohistochemical evidence of IL-4 localization to human mast cells of the skin and respiratory tract, and demonstrate that immunoglobulin E-dependent stimulation of purified human lung mast cells leads to the rapid release of IL-4 into the extracellular environment. We propose that mast cell activation in an allergic response provides a rapid and local pulse of IL-4 into the local environment essential for the triggering of T lymphocytes into sustained IL-4 production and to initiate inflammatory cell accumulation and activation.
DOI Link: 10.1084/jem.176.5.1381
ISSN: 0022-1007
Type: Journal Article
Rights: Creative Commons Attribution Non-Commercial License
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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