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Title: Bronchial hyperresponsiveness: insights into new signaling molecules.
Authors: Amrani, Y
Tliba, O
Deshpande, DA
Walseth, TF
Kannan, MS
Panettieri, RA
First Published: Jun-2004
Citation: CURR OPIN PHARMACOL, 2004, 4 (3), pp. 230-234
Abstract: Signaling molecules play a critical role in the pathophysiology of airway diseases. Recent evidence shows that cyclic ADP-ribose (cADPr), an endogenous activator of the ryanodine receptor channel in mammalian cells, modulates agonist-induced calcium responses in airway smooth muscle (ASM) cells. In addition, cADPr-mediated calcium release appears to play an important role in the "non-specific" increased ASM responsiveness to contractile agonists in cytokine-treated cells, a characteristic finding of asthma. Furthermore, other signaling molecules such as Rho/Rho kinase and phosphodiesterase also contribute to bronchial hyperresponsiveness. Thus, a better understanding of these signaling molecules that alter calcium signaling and contractility of ASM might provide new insight into novel therapeutic targets for the control of bronchial hyperresponsiveness.
DOI Link: 10.1016/j.coph.2004.02.004
ISSN: 1471-4892
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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