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Title: Once versus three-times daily regimens of tobramycin treatment for pulmonary exacerbations of cystic fibrosis--the TOPIC study: a randomised controlled trial.
Authors: Smyth, A
Tan, KH
Hyman-Taylor, P
Mulheran, M
Lewis, S
Stableforth, D
Prof Knox A
TOPIC Study Group
First Published: 12-Feb-2005
Citation: LANCET, 2005, 365 (9459), pp. 573-578
Abstract: Intravenous tobramycin (three-times daily) is widely used for pulmonary exacerbations in patients with cystic fibrosis who have chronic Pseudomonas aeruginosa infection. We undertook a double-blind, randomised controlled trial to assess the safety and efficacy of once versus three-times daily tobramycin in these patients.
DOI Link: 10.1016/S0140-6736(05)17906-9
eISSN: 1474-547X
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Medical and Social Care Education

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