Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/23253
Title: A RhoGDP dissociation inhibitor spatially regulates growth in root hair cells.
Authors: Carol, RJ
Takeda, S
Linstead, P
Durrant, MC
Kakesova, H
Derbyshire, P
Drea, S
Zarsky, V
Dolan, L
First Published: 15-Dec-2005
Citation: NATURE, 2005, 438 (7070), pp. 1013-1016
Abstract: Root hairs are cellular protuberances extending from the root surface into the soil; there they provide access to immobile inorganic ions such as phosphate, which are essential for growth. Their cylindrical shape results from a polarized mechanism of cell expansion called tip growth in which elongation is restricted to a small area at the surface of the hair-forming cell (trichoblast) tip. Here we identify proteins that spatially control the sites at which cell growth occurs by isolating Arabidopsis mutants (scn1) that develop ectopic sites of growth on trichoblasts. We cloned SCN1 and showed that SCN1 is a RhoGTPase GDP dissociation inhibitor (RhoGDI) that spatially restricts the sites of growth to a single point on the trichoblast. We showed previously that localized production of reactive oxygen species by RHD2/AtrbohC NADPH oxidase is required for hair growth; here we show that SCN1/AtrhoGDI1 is a component of the mechanism that focuses RHD2/AtrbohC-catalysed production of reactive oxygen species to hair tips during wild-type development. We propose that the spatial organization of growth in plant cells requires the local RhoGDI-regulated activation of the RHD2/AtrbohC NADPH oxidase.
DOI Link: 10.1038/nature04198
eISSN: 1476-4687
Links: http://hdl.handle.net/2381/23253
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Biology

Files in This Item:
There are no files associated with this item.


Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.