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Title: Abdominal aortic aneurysm rupture is associated with increased medial neovascularization and overexpression of proangiogenic cytokines.
Authors: Choke, E
Thompson, MM
Dawson, J
Wilson, WR
Sayed, S
Loftus, IM
Cockerill, GW
First Published: Sep-2006
Citation: ARTERIOSCLER THROMB VASC BIOL, 2006, 26 (9), pp. 2077-2082
Abstract: Matrix metalloproteinase (MMP) activity has been linked to abdominal aortic aneurysm (AAA) rupture. Medial neovascularization (MNV), a histopathologic characteristic of AAAs, involves proteolytic degradation of extracellular matrix by MMPs to facilitate endothelial cell migration. The role of MNV in aneurysm rupture is unknown. This study investigated whether MNV is increased in aneurysm rupture.
DOI Link: 10.1161/01.ATV.0000234944.22509.f9
eISSN: 1524-4636
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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