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Title: A systematic review of systematic reviews and meta-analyses of animal experiments with guidelines for reporting.
Authors: Peters, JL
Sutton, AJ
Jones, DR
Rushton, L
Abrams, KR
First Published: 2006
Citation: J ENVIRON SCI HEALTH B, 2006, 41 (7), pp. 1245-1258
Abstract: To maximize the findings of animal experiments to inform likely health effects in humans, a thorough review and evaluation of the animal evidence is required. Systematic reviews and, where appropriate, meta-analyses have great potential in facilitating such an evaluation, making efficient use of the animal evidence while minimizing possible sources of bias. The extent to which systematic review and meta-analysis methods have been applied to evaluate animal experiments to inform human health is unknown. Using systematic review methods, we examine the extent and quality of systematic reviews and meta-analyses of in vivo animal experiments carried out to inform human health. We identified 103 articles meeting the inclusion criteria: 57 reported a systematic review, 29 a systematic review and a meta-analysis, and 17 reported a meta-analysis only. The use of these methods to evaluate animal evidence has increased over time. Although the reporting of systematic reviews is of adequate quality, the reporting of meta-analyses is poor. The inadequate reporting of meta-analyses observed here leads to questions on whether the most appropriate methods were used to maximize the use of the animal evidence to inform policy or decision-making. We recommend that guidelines proposed here be used to help improve the reporting of systematic reviews and meta-analyses of animal experiments. Further consideration of the use and methodological quality and reporting of such studies is needed.
DOI Link: 10.1080/10934520600655507
ISSN: 0360-1234
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Health Sciences

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