Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/23313
Title: Oxidised phospholipid regulation of Toll-like receptor signalling.
Authors: Erridge, C
Spickett, CM
First Published: 2007
Citation: REDOX REP, 2007, 12 (1), pp. 76-80
Abstract: Toll-like receptors (TLRs) serve to initiate inflammatory signalling in response to the detection of conserved microbial molecules or products of host tissue damage. Recent evidence suggests that TLR-signalling plays a considerable role in a number of inflammatory diseases, including atherosclerosis and arthritis. Agents which modulate TLR-signalling are, therefore, receiving interest in terms of their potential to modify inflammatory disease processes. One such family of molecules, the oxidised phospholipids (OxPLs), which are formed as a result of inflammatory events and accumulate at sites of chronic inflammation, have been shown to modulate TLR-signalling in both in vitro and in vivo systems. As the interaction between OxPLs and TLRs may play a significant role in chronic inflammatory disease processes, consideration is given in this review to the potential role of OxPLs in the regulation of TLR-signalling.
DOI Link: 10.1179/135100007X162121
eISSN: 1743-2928
Links: http://hdl.handle.net/2381/23313
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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