Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/23324
Title: Circadian changes in Drosophila motor terminals.
Authors: Mehnert, KI
Beramendi, A
Elghazali, F
Negro, P
Kyriacou, CP
Cantera, R
First Published: Mar-2007
Citation: DEV NEUROBIOL, 2007, 67 (4), pp. 415-421
Abstract: In Drosophila melanogaster, as in most other higher organisms, a circadian clock controls the rhythmic distribution of rest/sleep and locomotor activity. Here we report that the morphology of Drosophila flight neuromuscular terminals changes between day and night, with a rhythm in synaptic bouton size that continues in constant darkness, but is abolished during aging. Furthermore, arrhythmic mutations in the clock genes timeless and period also disrupt this circadian rhythm. Finally, these clock mutants also have an opposing effect on the nonrhythmic phenotype of neuronal branching, with tim mutants showing a dramatic hyperbranching morphology and per mutants having fewer branches than wild-type flies. These unexpected results reveal further circadian as well as nonclock related pleiotropic effects for these classic behavioral mutants.
DOI Link: 10.1002/dneu.20332
ISSN: 1932-8451
Links: http://hdl.handle.net/2381/23324
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Genetics

Files in This Item:
There are no files associated with this item.


Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.