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Title: The role of microRNAs (miRNA) in circadian rhythmicity
Authors: Pegoraro, Mirko
Tauber, Eran
First Published: Dec-2008
Publisher: Indian Academy of Sciences
Citation: Journal of Genetics, 2008, 87 (5), pp. 505-511
Abstract: MicroRNA (miRNA) is a recently discovered new class of small RNA molecules that have a significant role in regulating gene and protein expression. These small RNAs (∼22 nt) bind to 3′ untranslated regions (3′ UTRs) and induce degradation or repression of translation of their mRNA targets. Hundreds of miRNAs have been identified in various organisms and have been shown to play a significant role in development and normal cell functioning. Recently, a few studies have suggested that miRNAs may be an important regulators of circadian rhythmicity, providing a new dimension (posttranscriptional) of our understanding of biological clocks. Here, we describe the mechanisms of miRNA regulation, and recent studies attempting to identify clock miRNAs and their function in the circadian system.
DOI Link: 10.1007/s12041-008-0073-8
ISSN: 0022-1333
eISSN: 0973-7731
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2008, Indian Academy of Sciences with Springer Verlag. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.
Appears in Collections:Published Articles, Dept. of Genetics

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