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Title: Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies.
Authors: Schosser, A
Gaysina, D
Cohen-Woods, S
Chow, PC
Martucci, L
Craddock, N
Farmer, A
Korszun, A
Gunasinghe, C
Gray, J
Jones, L
Tozzi, F
Perry, J
Muglia, P
Owen, MJ
Craig, IW
McGuffin, P
First Published: Aug-2010
Citation: MOL PSYCHIATRY, 2010, 15 (8), pp. 844-849
Abstract: The gene known as Disrupted-in-Schizophrenia-1, DISC1, was originally discovered in a large family, in which it also co-segregated with bipolar affective disorder (BD) and with major depressive disorder (MDD). The TSNAX (Translin-associated factor X) gene, located immediately upstream of DISC1, has also been suggested as a candidate gene in relation to psychiatric illness, as one transcript resulting from intergenic splicing encodes a novel TSNAX-DISC1 fusion protein. We explored the TSNAX-DISC1 gene region for an association with BD and MDD in a sample of 1984 patients (1469 MDD, 515 BD) and 1376 ethnically matched controls. Eight single nucleotide polymorphisms (SNPs) within the TSNAX-DISC1 region (rs766288, rs3738401, rs2492367, rs6675281, rs12133766, rs1000731, rs7546310 and rs821597) were investigated using the SNPlex Genotyping System. We found a significant allelic and genotypic association of the TSNAX-DISC1 gene region with BD, whereas a haplotypic association was found for both BD and MDD. Therefore, our results suggest an association between the TSNAX-DISC1 region and both forms of affective disorders, and support the hypothesis that a portion of the genotypic overlap between schizophrenia and affective disorders is attributable to this gene.
DOI Link: 10.1038/mp.2009.21
eISSN: 1476-5578
Type: Journal Article
Appears in Collections:Published Articles, School of Psychology

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