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Title: Insulin U-500 in severe insulin resistance in type 2 diabetes mellitus.
Authors: Crasto, W
Jarvis, J
Hackett, E
Nayyar, V
McNally, PG
Davies, MJ
Lawrence, IG
First Published: Apr-2009
Citation: POSTGRAD MED J, 2009, 85 (1002), pp. 219-222
Abstract: Some patients with type 2 diabetes mellitus (T2DM) are profoundly insulin resistant and require large insulin doses to achieve optimal glycaemic control. However, large volumes of subcutaneous conventional U-100 insulin can cause discomfort at the injection site, resulting in poor concordance with insulin therapy. One therapeutic option is the use of U-500 insulin, thus reducing the insulin volume by 80%. This review will address the practical issues associated with the use of U-500, clinical efficacy and safety aspects of this concentrated insulin, which has an important role in a subgroup of patients with T2DM.
DOI Link: 10.1136/pgmj.2008.073379
eISSN: 1469-0756
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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