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Title: Imprinting of the polycomb group gene MEDEA serves as a ploidy sensor in Arabidopsis.
Authors: Erilova, A.
Brownfield, Lynette
Exner, V.
Rosa, M.
Twell, David
Mittelsten Scheid O.
Hennig, L.
Köhler, C.
First Published: 25-Sep-2009
Publisher: Public Library of Science
Citation: PLoS Genetics, 2009, 5 (9), pp. e1000663-e1000663
Abstract: Balanced maternal and paternal genome contributions are a requirement for successful seed development. Unbalanced contributions often cause seed abortion, a phenomenon that has been termed "triploid block." Misregulation of imprinted regulatory genes has been proposed to be the underlying cause for abnormalities in growth and structure of the endosperm in seeds with deviating parental contributions. We identified a mutant forming unreduced pollen that enabled us to investigate direct effects of unbalanced parental genome contributions on seed development and to reveal the underlying molecular mechanism of dosage sensitivity. We provide evidence that parent-of-origin-specific expression of the Polycomb group (PcG) gene MEDEA is causally responsible for seed developmental aberrations in Arabidopsis seeds with increased paternal genome contributions. We propose that imprinted expression of PcG genes is an evolutionary conserved mechanism to balance parental genome contributions in embryo nourishing tissues.
DOI Link: 10.1371/journal.pgen.1000663
ISSN: 1553-7390
eISSN: 1553-7404
Type: Journal Article
Rights: Copyright: © 2009 Erilova et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Description: Competing interests: European patent EP09008196 “Polyploid plants” was deposited by ETH on June 23rd, 2009.
Appears in Collections:Published Articles, Dept. of Biology

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