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Title: Variation in IGHMBP2 is not associated with IgA nephropathy in independent studies of UK Caucasian and Chinese Han patients.
Authors: Lou, T
Zhang, J
Gale, DP
Rees, AJ
Rhodes, B
Feehally, J
Li, C
Li, Y
Li, R
Huang, W
Hu, B
Leung, JC
Lam, MF
Lai, KN
Wang, Y
Maxwell, PH
First Published: May-2010
Citation: NEPHROL DIAL TRANSPLANT, 2010, 25 (5), pp. 1547-1554
Abstract: IgA nephropathy is a major cause of end-stage renal disease worldwide. Its aetiology is poorly understood but there is good evidence for a major genetic component, although to date, no gene has been conclusively identified. We describe a new UK multicentre DNA collection assembled to investigate this. A Japanese genome-wide analysis recently reported that common genetic variation in immunoglobulin mu-binding protein 2 (IGHMBP2) was associated with IgA nephropathy. We sought to replicate this using the new UK collection, and through an independent parallel analysis of a Han Chinese population.
DOI Link: 10.1093/ndt/gfp661
eISSN: 1460-2385
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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