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Title: Physical interactions between mast cells and eosinophils: a novel mechanism enhancing eosinophil survival in vitro.
Authors: Elishmereni, M
Alenius, HT
Bradding, P
Mizrahi, S
Shikotra, A
Minai-Fleminger, Y
Mankuta, D
Eliashar, R
Zabucchi, G
Levi-Schaffer, F
First Published: Mar-2011
Citation: ALLERGY, 2011, 66 (3), pp. 376-385
Abstract: Mast cells (MCs) and eosinophils (Eos) are the key effector cells of the allergic reaction. Although classically associated with different stages of the response, the cells co-exist in the inflamed tissue in the late and chronic phases in high numbers and are likely to cross-talk. While some mediators of MCs are known to affect Eos biology and vice versa, paracrine and physical interplay between the two cells has not been described yet. We aimed to investigate whether intercellular MC-Eos communication could take place in the allergic response and exert functional bidirectional changes on the cells.
DOI Link: 10.1111/j.1398-9995.2010.02494.x
eISSN: 1398-9995
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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