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|Title:||Utility of the pooling approach as applied to whole genome association scans with high-density Affymetrix microarrays.|
|Citation:||BMC RES NOTES, 2010, 3, pp. 274-274|
|Abstract:||We report an attempt to extend the previously successful approach of combining SNP (single nucleotide polymorphism) microarrays and DNA pooling (SNP-MaP) employing high-density microarrays. Whereas earlier studies employed a range of Affymetrix SNP microarrays comprising from 10 K to 500 K SNPs, this most recent investigation used the 6.0 chip which displays 906,600 SNP probes and 946,000 probes for the interrogation of CNVs (copy number variations). The genotyping assay using the Affymetrix SNP 6.0 array is highly demanding on sample quality due to the small feature size, low redundancy, and lack of mismatch probes.|
|Appears in Collections:||Published Articles, School of Psychology|
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