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Title: Heat shock protein 70 expression following hepatic radiofrequency ablation is affected by adjacent vasculature.
Authors: Bhardwaj, N
Dormer, J
Ahmad, F
Strickland, AD
Gravante, G
Beckingham, I
West, K
Dennison, AR
Lloyd, DM
First Published: Apr-2012
Citation: J SURG RES, 2012, 173 (2), pp. 249-257
Abstract: Heat shock proteins are a highly conserved family of stress response proteins. Members of the heat shock protein 70 (Hsp70) family prevent protein misfolding and aggregation. Following radiofrequency ablation of unresectable liver tumors an interface appears between the irreversibly damaged and normal liver. The fate of this transition zone is critical and is believed to be responsible for local recurrences. Hsp70 is expressed in response to thermal stress and may influence the fate of cells in this transitional zone. It is also recognized that the presence of large vessels or a perivascular location of tumors also influences the recurrence rate. The aim of this study is to examine the transition zone and observe the effect of local blood flow on ablation morphology and Hsp70 expression.
DOI Link: 10.1016/j.jss.2010.09.040
eISSN: 1095-8673
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Medical and Social Care Education

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