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Title: Naked small interfering RNA of caspase-3 in preservation solution and autologous blood perfusate protects isolated ischemic porcine kidneys.
Authors: Yang, B
Hosgood, SA
Nicholson, ML
First Published: 15-Mar-2011
Citation: TRANSPLANTATION, 2011, 91 (5), pp. 501-507
Abstract: Ischemia-reperfusion injury (IRI) plays key roles in graft viability and posttransplantation function. Caspase-3 associated with apoptosis and inflammation is up-regulated by IRI. We propose that naked small interfering RNA (siRNA) targeting caspase-3 may prevent IRI and improve kidney preservation.
DOI Link: 10.1097/TP.0b013e318207949f
eISSN: 1534-6080
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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