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Title: DNA sequence analysis of the imp UV protection and mutation operon of the plasmid TP110: identification of a third gene
Authors: Lodwick, D.
Owen, D.
Strike, P.
First Published: 11-Sep-1990
Publisher: Oxford University Press
Citation: Nucleic Acids Research, 1990, 18 (17), pp. 5045-5050
Abstract: The sequence of the imp operon of the plasmid TP110 (which belongs to the Incl[subscript: 1] incompatibility group) has been determined, and is shown to contain three open reading frames. This operon, involved in UV protection and mutation, is functionally analogous to the umuDC operon of E.coli and the mucAB operon of the plasmid pKM101, which belongs to the quite unrelated IncN incompatibility group. The umu and muc operons however contain only two open reading frames, coding for proteins of approximately 16kD and 46kD. The high degree of homology between the two 16kD proteins (UmuD and MucA) and between the two 46kD proteins (UmuC and MucB) clearly shows their relatedness. This is shown also to extend to the imp gene products, with ImpA sharing homology with UmuD and MucA, and ImpB sharing homology with UmuC and MucB. However, the two imp genes are preceded in the operon by a third gene, impC, which encodes a small protein of 9.5kD and which has no equivalent in the umu and muc operons.
DOI Link: 10.1093/nar/18.17.5045
ISSN: 0305-1048
Type: Journal Article
Rights: Copyright © 1990 Oxford University Press
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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