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Title: Protein kinase C-independent inhibition of arterial smooth muscle K(+) channels by a diacylglycerol analogue.
Authors: Rainbow, R
Parker, A
Davies, N
First Published: Jun-2011
Citation: BR J PHARMACOL, 2011, 163 (4), pp. 845-856
Abstract: Analogues of the endogenous diacylglycerols have been used extensively as pharmacological activators of protein kinase C (PKC). Several reports show that some of these compounds have additional effects that are independent of PKC activation, including direct block of K(+) and Ca(2+) channels. We investigated whether dioctanoyl-sn-glycerol (DiC8), a commonly used diacylglycerol analogue, blocks K(+) currents of rat mesenteric arterial smooth muscle in a PKC-independent manner.
DOI Link: 10.1111/j.1476-5381.2011.01268.x
eISSN: 1476-5381
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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