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|Title:||Protein kinase C-independent inhibition of arterial smooth muscle K(+) channels by a diacylglycerol analogue.|
|Citation:||BR J PHARMACOL, 2011, 163 (4), pp. 845-856|
|Abstract:||Analogues of the endogenous diacylglycerols have been used extensively as pharmacological activators of protein kinase C (PKC). Several reports show that some of these compounds have additional effects that are independent of PKC activation, including direct block of K(+) and Ca(2+) channels. We investigated whether dioctanoyl-sn-glycerol (DiC8), a commonly used diacylglycerol analogue, blocks K(+) currents of rat mesenteric arterial smooth muscle in a PKC-independent manner.|
|Appears in Collections:||Published Articles, Dept. of Cardiovascular Sciences|
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