Please use this identifier to cite or link to this item:
Title: The meta-analysis of genome-wide association studies.
Authors: Thompson, JR
Attia, J
Minelli, C
First Published: May-2011
Citation: BRIEF BIOINFORM, 2011, 12 (3), pp. 259-269
Abstract: The pressure to publish novel genetic associations has meant that meta-analysis has been applied to genome-wide association studies without the time for a careful consideration of the methods that are used. This review distinguishes between the use of meta-analysis to validate previously reported genetic associations and its use for gene discovery, and advocates viewing gene discovery as an exploratory screen that requires independent replication instead of treating it as the application of hundreds of thousands of statistical tests. The review considers the use of fixed and random effects meta-analyses, the investigation of between-study heterogeneity, adjustment for confounding, assessing the combined evidence and genomic control, and comments on alternative approaches that have been used in the literature.
DOI Link: 10.1093/bib/bbr020
eISSN: 1477-4054
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Health Sciences

Files in This Item:
There are no files associated with this item.

Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.