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Title: Vagus nerve stimulation protects against ventricular fibrillation independent of muscarinic receptor activation.
Authors: Brack, KE
Coote, JH
Ng, GA
First Published: 1-Aug-2011
Citation: CARDIOVASC RES, 2011, 91 (3), pp. 437-446
Abstract: The role of the vagus in the ventricle is controversial, although the vagus can protect against ventricular fibrillation (VF) via nitric oxide (NO). This study aims to determine whether the mechanisms involved are dependent on post-ganglionic release and muscarinic receptor activation. For this purpose, NO release and electrophysiological effects of vagus nerve stimulation (VNS) were evaluated in relation to acetylcholine and vasoactive intestinal peptide (VIP). In addition, the role of the coronary endothelium and afferent nerves was tested.
DOI Link: 10.1093/cvr/cvr105
eISSN: 1755-3245
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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