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|Title:||Molecular basis of selective antagonism of the P2X1 receptor for ATP by NF449 and suramin: contribution of basic amino acids in the cysteine-rich loop.|
|Citation:||BR J PHARMACOL, 2012, 165 (2), pp. 390-400|
|Abstract:||The cysteine-rich head region, which is adjacent to the proposed ATP-binding pocket in the extracellular ligand-binding loop of P2X receptors for ATP, is absent in the antagonist-insensitive Dictyostelium receptors. In this study we have determined the contribution of the head region to the antagonist action of NF449 and suramin at the human P2X1 receptor.|
|Appears in Collections:||Published Articles, Dept. of Cell Physiology and Pharmacology|
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