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Title: Inherited IgA glycosylation pattern in IgA nephropathy and HSP nephritis: where do we go next?
Authors: Boyd, JK
Barratt, J
First Published: Jul-2011
Citation: KIDNEY INT, 2011, 80 (1), pp. 8-10
Abstract: New data from Kiryluk et al. show the importance of genetic factors in determining the profile of serum IgA1 O-glycoforms in IgA nephropathy and Henoch-Schönlein purpura nephritis. Elevated serum levels of poorly galactosylated IgA1 O-glycoforms do not, however, appear sufficient in themselves to cause nephritis in these two diseases, and a 'second hit' is necessary before changes in IgA1 glycosylation translate into clinical disease. The challenge now is to determine what these genetic factors are.
DOI Link: 10.1038/ki.2011.83
eISSN: 1523-1755
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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