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|Title:||Inherited IgA glycosylation pattern in IgA nephropathy and HSP nephritis: where do we go next?|
|Citation:||KIDNEY INT, 2011, 80 (1), pp. 8-10|
|Abstract:||New data from Kiryluk et al. show the importance of genetic factors in determining the profile of serum IgA1 O-glycoforms in IgA nephropathy and Henoch-Schönlein purpura nephritis. Elevated serum levels of poorly galactosylated IgA1 O-glycoforms do not, however, appear sufficient in themselves to cause nephritis in these two diseases, and a 'second hit' is necessary before changes in IgA1 glycosylation translate into clinical disease. The challenge now is to determine what these genetic factors are.|
|Appears in Collections:||Published Articles, Dept. of Infection, Immunity and Inflammation|
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