Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/23839
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dc.contributor.authorTurnbull, C-
dc.contributor.authorSeal, S-
dc.contributor.authorRenwick, A-
dc.contributor.authorWarren-Perry, M-
dc.contributor.authorHughes, D-
dc.contributor.authorElliott, A-
dc.contributor.authorPernet, D-
dc.contributor.authorPeock, S-
dc.contributor.authorAdlard, JW-
dc.contributor.authorBarwell, J-
dc.contributor.authorBerg, J-
dc.contributor.authorBrady, AF-
dc.contributor.authorBrewer, C-
dc.contributor.authorBrice, G-
dc.contributor.authorChapman, C-
dc.contributor.authorCook, J-
dc.contributor.authorDavidson, R-
dc.contributor.authorDonaldson, A-
dc.contributor.authorDouglas, F-
dc.contributor.authorGreenhalgh, L-
dc.contributor.authorHenderson, A-
dc.contributor.authorIzatt, L-
dc.contributor.authorKumar, A-
dc.contributor.authorLalloo, F-
dc.contributor.authorMiedzybrodzka, Z-
dc.contributor.authorMorrison, PJ-
dc.contributor.authorPaterson, J-
dc.contributor.authorPorteous, M-
dc.contributor.authorRogers, MT-
dc.contributor.authorShanley, S-
dc.contributor.authorWalker, L-
dc.contributor.authorBreast Cancer Susceptibility Collaboration (UK)-
dc.contributor.authorEMBRACE-
dc.contributor.authorAhmed, M-
dc.contributor.authorEccles, D-
dc.contributor.authorEvans, DG-
dc.contributor.authorDonnelly, P-
dc.contributor.authorEaston, DF-
dc.contributor.authorStratton, MR-
dc.contributor.authorRahman, N-
dc.date.accessioned2012-10-24T09:13:58Z-
dc.date.available2012-10-24T09:13:58Z-
dc.date.issued2012-2-15-
dc.identifier.citationHUM MOL GENET, 2012, 21 (4), pp. 958-962-
dc.identifier.urihttp://hdl.handle.net/2381/23839-
dc.description.abstractThere have been few definitive examples of gene-gene interactions in humans. Through mutational analyses in 7325 individuals, we report four interactions (defined as departures from a multiplicative model) between mutations in the breast cancer susceptibility genes ATM and CHEK2 with BRCA1 and BRCA2 (case-only interaction between ATM and BRCA1/BRCA2 combined, P = 5.9 × 10(-4); ATM and BRCA1, P= 0.01; ATM and BRCA2, P= 0.02; CHEK2 and BRCA1/BRCA2 combined, P = 2.1 × 10(-4); CHEK2 and BRCA1, P= 0.01; CHEK2 and BRCA2, P= 0.01). The interactions are such that the resultant risk of breast cancer is lower than the multiplicative product of the constituent risks, and plausibly reflect the functional relationships of the encoded proteins in DNA repair. These findings have important implications for models of disease predisposition and clinical translation.-
dc.formatmetadata-
dc.language.isoeng-
dc.sourcePubMed-
dc.source.urihttp://www.ncbi.nlm.nih.gov/pubmed/-
dc.subjectBreast Neoplasms-
dc.subjectCell Cycle Proteins-
dc.subjectDNA Mutational Analysis-
dc.subjectDNA-Binding Proteins-
dc.subjectFamily Health-
dc.subjectFemale-
dc.subjectGenes-
dc.subjectBRCA1-
dc.subjectGenes-
dc.subjectBRCA2-
dc.subjectGenetic Predisposition to Disease-
dc.subjectGreat Britain-
dc.subjectHumans-
dc.subjectModels-
dc.subjectGenetic-
dc.subjectPedigree-
dc.subjectProtein-Serine-Threonine Kinases-
dc.subjectTumor Suppressor Proteins-
dc.titleGene-gene interactions in breast cancer susceptibility.-
dc.typeJournal Article-
dc.identifier.doi10.1093/hmg/ddr525-
dc.identifier.eissn1460-2083-
dc.identifier.piiddr525-
dc.description.irispid76335-
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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