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Title: Resolution-dependent estimates of lesion volumes in magnetic resonance imaging studies of the brain in multiple sclerosis.
Authors: Filippi, M
Horsfield, MA
Campi, A
Mammi, S
Pereira, C
Comi, G
First Published: Nov-1995
Citation: ANN NEUROL, 1995, 38 (5), pp. 749-754
Abstract: In this study, we investigated the relationship between multiple sclerosis lesion volumes measured from magnetic resonance imaging scans and image-slice thickness. The lesion volume was computed using a semiautomated thresholding technique from axial scans of the brain of varying slice thickness. Ten patients were studied, and in all cases the computed lesion volume increased with decreasing slice thickness (p = 0.01). Linear extrapolation from our data allowed the lesion volume at very small slice thickness to be estimated; this was found to be on average 20% greater than that obtained using a slice thickness of 5 mm. Furthermore, there were considerable differences in the percentage of change in lesion volume from patient to patient, and it would appear that there is a larger variation with slice thickness for patients with smaller lesions and higher lesion loads.
DOI Link: 10.1002/ana.410380509
ISSN: 0364-5134
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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