Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/24200
Title: Guidelines for using quantitative measures of brain magnetic resonance imaging abnormalities in monitoring the treatment of multiple sclerosis.
Authors: Filippi, M
Horsfield, MA
Adèr, HJ
Barkhof, F
Bruzzi, P
Evans, A
Frank, JA
Grossman, RI
McFarland, HF
Molyneux, P
Paty, DW
Simon, J
Tofts, PS
Wolinsky, JS
Miller, DH
First Published: Apr-1998
Citation: ANN NEUROL, 1998, 43 (4), pp. 499-506
Abstract: The change of brain lesion load, measured on T2-weighted magnetic resonance imaging (MRI) using computer-assisted techniques, is a widely used secondary endpoint for phase III clinical trials in multiple sclerosis (MS). Collection, transfer, and analysis of the electronic data across multiple centers have all proved challenging and give rise to potential errors. However, many new acquisition schemes and postprocessing techniques have been developed; these may reduce scan times and result in better lesion conspicuity or lessen the human interaction needed for data analysis. This review considers many aspects of the use of MRI in clinical trials for MS and provides international consensus guidelines, derived from a task force of the European Magnetic Resonance Networks in Multiple Sclerosis (MAGNIMS) together with a group of North American experts. The main points considered are the organization of correctly powered trials and selection of participating sites; the appropriate choice of pulse sequences and image acquisition protocol given the current state of technology; quality assurance for data acquisition and analysis; accuracy and reproducibility of lesion load assessments; and the potential for the application of quantitative methods to other MRI-derived measures of disease burden.
DOI Link: 10.1002/ana.410430414
ISSN: 0364-5134
Links: http://hdl.handle.net/2381/24200
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

Files in This Item:
There are no files associated with this item.


Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.