Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/24352
Title: Epoetin alpha prevents anaemia and reduces transfusion requirements in patients undergoing primarily platinum-based chemotherapy for small cell lung cancer
Authors: Thatcher, N.
De Campos, E. S.
Bell, D. R.
Steward, W. P.
Varghese, G.
Morant, R.
Vansteenkiste, J. F.
Rosso, R.
Ewers, S. B.
Sundal, E.
Schatzmann, E.
Stocker, H.
First Published: 1-May-1999
Publisher: Cancer Research UK, Nature Publishing Group
Citation: British Journal of Cancer (1999) 80, 396–402.
Abstract: Anaemia commonly occurs in cancer patients receiving chemotherapy, often necessitating blood transfusion. This multicentre study was designed to evaluate the efficacy and safety of epoetin α in preventing the decline in haemoglobin (Hb) level, and to determine whether the transfusion requirement could be reduced, in patients receiving 4–6 cycles of primarily platinum-based combination cyclic chemotherapy for small cell lung cancer (SCLC). A total of 130 non-anaemic SCLC patients were randomized to receive no additional treatment (n = 44), epoetin α 150 IU kg–1 subcutaneously (s.c.) three times a week (n = 42) or 300 IU kg–1 s.c. three times a week (n = 44). Reductions in epoetin α dosage were made during the study if Hb level increased to >15 g dl–1. The mean weekly dosage was 335 and 612 IU kg–1, respectively, in the two active treatment groups. Significantly fewer (P < 0.05) epoetin α-treated patients experienced anaemia (Hb < 10 g dl–1) during the course of chemotherapy (300 IU kg–1, 39%; 150 IU kg–1, 48%; untreated, 66%). This was reflected in the significantly lower number of treated patients transfused [300 IU kg–1, 20% (P < 0.001); 150 IU kg–1, 45% (P < 0.05); untreated, 59%]. Epoetin α was well-tolerated, and there was no evidence of sustained, clinically significant, hypertension. In summary, epoetin α is effective and well-tolerated in maintaining Hb level and reducing transfusion requirement in patients undergoing cyclic chemotherapy for SCLC.
DOI Link: 10.1038/sj.bjc.6690369
ISSN: 0007-0920
Links: http://hdl.handle.net/2381/24352
http://www.nature.com/bjc/journal/v80/n3/abs/6690369a.html
Type: Journal Article
Rights: Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine



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